First, I'd suggest that you go to a Lexus dealer and get yourself an OEM timing belt for that motor and put it on.
The aftermarket belts, even the well known ones like Gates sometimes do not fit like the OEM belt, and the tensioner can't put enough tension on it to keep it from jumping. I installed/reinstalled a brand new Gates belt on my motor at least a dozen times and it kept jumping time until we finally had to "shim" the arm of the tensioner to get the belt tight enough.
Secondly, when the engine is running, hang a timing light on each plug wire in turn and see if you're getting a nice steady pulse to each plug. This is an easy way to look for ignition misfires. If you find intermittent spark on a cylinder, then test the spark plug cables with your DVM and see if any of them read abnormally high compared to the rest. Do be very careful when you remove the cables as they're easily damaged.
Thirdly, go to a NAPA store and pick up a block test kit, NAPA P/N: [FONT=arial,arial,helvetica]700-1006. This will tell you whether you have combustion gasses in your coolant, which could be why you're overheating, ie a blown head gasket. If you don't know the history of that motor, there could be a number of things wrong with it.
If you're sure that fuel is "accumulating" in cylinder 6, then you're not getting spark there and you just have to trace things back from the plug to find out why.
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