Ahhhh. been there, done that on my 3vz-fe v6 with my smt6.
I used a set of relays to cut off the front bank fuel injectors, tied the two o2 sensors together & corrected the fuel trim on my smt6 to keep the ECU happy & wound up having to cut the spark to the front bank too.
Im sure someone could do infinately better than I could. To me, it didn't really do much more than make the engine very, very unresponcive. Didn't like cruising on the highway without 75%+ throttle. Doesn't really do much for me. Like anyhting it's a balance. The idea is that one bank of cylinders pulling through a larger throttle opening are more effecient even after losses. The problem is without cam trickery, you're inccuring pumping losses.
That, most car engine guys can pick-up on as a first thoguht.
What they normally don't consider is ignition. You're still gunna suck fuel into the cylinders if you can't keep the intake valves closed on the dead cylinders. If you're sucking fuel, even if it's super lean, you're gunna burn it. It may not on a cold engine, but it sure will when it hits that hot combustion chamber!
That was my experiance with it. I don't want to sound like an expert, or anything. Heck, I'm bearly able to remember my grandfather cussing his 4-6-8 left and right. But unlike alot of people that talk about it, I did actually try it for awhile.

It's good to drive down the driveway I guess if you can keep the ECU out of limp mode! (Where it may give you like 5mpg!)