I'd think a 5.0 litre 1UZ crate motor that could come out of the box already broken in, with a 350 BHP dyno sheet would turn the heads of many people in the mainstream that would normally buy a SBC or SBF crate motor for a project. At the end of the day, who really wants a 21st century supercar with modern technology throughout, but powered by a 50 year old SBC? OK, Vette owners, but those guys just aren't evolving fast enough....
It would be even more attractive if it were available either in NA or FI trim, with "reasonable" quality internals that'll survive up to 7500, and a simple EMS that doesn't require a rocket scientist to setup. Don't put in the "best" of everything because people couldn't afford it, but put middle of the road stuff in, and concentrate on making it all work well together while keeping it affordable.
Certainly Ford would have a tougher time selling their 4.6L Cammer for $15,000 if a smaller, lighter, better engineered 5.0l DOHC motor were available. That 4.6l motor is a monstrosity compared to the 1UZ.
Build it and they will come, especially if the price tag can be kept somewhere south of 10K USD.